Impure thoughts - Reflections on the Concept and Measurement of Purity in Synthetic Organic Chemistry

Introduction

This white paper critically examines the limitations of traditional LCMS-based purity measurements in synthetic chemistry, questioning commonly accepted simplifying assumptions. It explores how these assumptions can skew purity results and highlights the key role of advanced chemometric tools in delivering more accurate analyses. By refining LCMS methodologies with the aid of chemometric approaches, the paper demonstrates improvements in precision, decision-making, and reliability in chemical synthesis and analysis.

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